Inhibitor 3d models

 Bovine Trypsin with inhib

Tags:  protein 

crystallography 

interaction 

protease 

Model's Description:
Bovine Trypsin with inhibitor SGPI-P02 3D Model. Download Bovine Trypsin with inhibitor SGPI-P02 in various files formats such as Wavefront Object format, Autodesk FBX, DirectX 9.0, Stereo Lithography and HTML5 JSON format.
Based on PDB entry 2XTT. Bovine trypsin is a serine protease that cleaves next to positively charged amino acid side chains. SGPI-P02 is a modified serine protease inhibitor isolated from a desert locust 3D Model is ready to download for free, this model contains 102220 polygons.

 Inhibitor

Tags:  fanart 

b3d 

vines 

lol 

leagueoflegends 

butterflies 

inhibitor 

blender 

animation 

Model's Description:
Inhibitor 3D Model. Download Inhibitor in various files formats such as Wavefront Object format, Autodesk FBX, DirectX 9.0, Stereo Lithography and HTML5 JSON format.
Made this inhibitor for the League of Legends Fan Art Contest. I was not able to get the second piece finished for submission so I decided to animate this Inhibitor instead. Thanks for taking a look! :) - Inhibitor - 3D model by Cristian Villalobos (@flowpoly) 3D Model is ready to download for free, this model contains 4300 polygons.

 Rheb in Complex with Inhi

Tags: 

Model's Description:
Rheb in Complex with Inhibitor NR1 3D Model. Download Rheb in Complex with Inhibitor NR1 in various files formats such as Wavefront Object format, Autodesk FBX, DirectX 9.0, Stereo Lithography and HTML5 JSON format.
The mTORC1 (mechanistic target of rapamycin complex 1) protein complex (not shown) regulates cell metabolism and growth in response to nutrients and growth factors. Aberrant mTORC1 signalling pathways are implicated in the pathogenesis of chronic diseases, including metabolic and neurological disease, autoimmune disorders and various cancers (DOI: 10.1242/jcs.125773). First-generation mTORC1 inhibitors have been of limited success as they also perturb normal mTORC2 signalling within the cell. Crucially, the allosteric activation of mTORC1, and not mTORC2, is dependent on the binding of the GTPase protein Rheb to the mTOR constituent. Pharmacological inhibitors of Rheb have thus been developed as therapeutics for mTORC1-related disease (DOI: 10.1038/s41467-018-03035-z), such as the drug compound NR1 which is represented in the above model as bound to Rheb (PDB: 6BT0). Also highlighted are key residues on Rheb’s switch II domain that contribute to the action of NR1 as a potent and selective mTORC1 inhibitor 3D Model is ready to download for free, this model contains 27192 polygons.