Model's Description:
Rheb in Complex with Inhibitor NR1 3D Model.
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Rheb in Complex with Inhibitor NR1 in various files formats such as Wavefront Object format, Autodesk FBX, DirectX 9.0, Stereo Lithography and HTML5 JSON format.
The mTORC1 (mechanistic target of rapamycin complex 1) protein complex (not shown) regulates cell metabolism and growth in response to nutrients and growth factors. Aberrant mTORC1 signalling pathways are implicated in the pathogenesis of chronic diseases, including metabolic and neurological disease, autoimmune disorders and various cancers (DOI: 10.1242/jcs.125773). First-generation mTORC1 inhibitors have been of limited success as they also perturb normal mTORC2 signalling within the cell. Crucially, the allosteric activation of mTORC1, and not mTORC2, is dependent on the binding of the GTPase protein Rheb to the mTOR constituent. Pharmacological inhibitors of Rheb have thus been developed as therapeutics for mTORC1-related disease (DOI: 10.1038/s41467-018-03035-z), such as the drug compound NR1 which is represented in the above model as bound to Rheb (PDB: 6BT0). Also highlighted are key residues on Rheb’s switch II domain that contribute to the action of NR1 as a potent and selective mTORC1 inhibitor 3D Model is ready to download for free
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