Model's Description:
The Structure of 3C2I 3D Model.
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The Structure of 3C2I in various files formats such as Wavefront Object format, Autodesk FBX, DirectX 9.0, Stereo Lithography and HTML5 JSON format.
MeCP2 binds to methylated DNA and initiates gene silencing. The X-ray structure of of DNA-MBD cocrystals indicate that methyl groups are bounded to water highlighting the hydrophilic interaction. This enabled the MBD domains to indentify mCpG. MeCP2-DNA complex explores the siginificance of T158 and Y123. Mutation in T158 and Y123 leads to Rett's Syndrome. Y123 is essential for DNA binding and T158 is required for the stability of the Asx-ST motif. The Asx-ST motif and the methylated CpG leads to mutations in the MBD family. Further studies are required to understand the DNA-methylation signals in this protein 3D Model is ready to download for free
, this model contains 21090 polygons and 11120 vertices.
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